Review on some medicinal plants with hepatoprotective activities. Phytochemical composition of ethanolic and aqueous extracts of the leaves, stembark, root, fruits and seeds i. Jain5 1department of pharmacognosy, mcops, manipal576104, india. However, a scientific evaluation has not been performed. In vitro antioxidant studies were carried out with dpph, hrsa, no, frap and lpo assays. Antibacterial activity of plants 719 effective extracts are considered, e. Besides invitro free radical scavenging activity, the plant has been reported to contain different phenolic compounds thus empowering the plant with antioxidant properties 17,18. Biological screening of various medicinal plant extracts for. Hepatoprotective activity of melia azedarach leaf extract against simvastatin induced hepatotoxicity a. Samples of tragopogon porrifolius plant grown wild in palestine were extracted with different solvents. Research article comparative hepatoprotective activity of. Hepatoprotective activity of hypericum perforatum l. The antiproliferative activity was measured by mtt assay. Thirtysix rats were randomly divided into six groups of 6 replicates.
Forty four extracts from sixteen plants used traditionally as anticancer agents were evaluated in vitro for their antiproliferative activity against hep2, mcf7, and vero cell lines. The collected leaves were shade dried for 35 days and finally pulverized in to coarse powder. In animal experiments, the hepatotoxic group showed a coarse granulation on. Hepatoprotective activity of sphaeranthus amaranthoides whole plant in paracetamol induced hepatotoxicity in rats. In india, quite eighty seven plants square measure used in 33 patented propitiatory multiingredient plant formulations. Tragopogon porrifolius, commonly referred to as white salsify, is an edible herb used in folk medicine to treat cancer. Usende, 4 andafisubasiru 4 college of health sciences, ladoke akintola university of technology, ogbomoso, nigeria. The invitro antioxidant activity was estimated for different extracts on superoxide, hydroxyl and 1,1 diphenyl2picrylhydrazyl free radicals and the hepatoprotective activity of the. In view of this a study carried out to identify the hepatoprotective activity of plant parts leaf, bark, collar, flower and hypocotyls of ceriops decandra. Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. These plants are widely used in traditional medicine for their availability and cheap prices. Orthosiphon stamineus exhibited significant free radical scavenging activity with dpph ic 50 21.
Hepatoprotective and cardiac inhibitory activities of. Hepatoprotective activity of some indigenous plants. About 600 commercial herbal formulations with hepatoprotective activity. Malvaceae was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The leaves were collected from fields of kangra, himachal pradesh, india. Aqueous, saline buffer and acid extracts of different plant species were screened in vitro for. Evaluation of hepatoprotective activity of amoora rohituka. The ethanolic and aqueous extract of pongamia pinnata bark was procured from unico pharmaceuticals, ludhiana. Histological examination of the liver tissues supported the hepatoprotection. Investigations on antibacterial activity of leaf extracts of.
Different extracts from the plant have shown activity against hiv which has been achieved by a different mechanism like inhibition of integrase activity 19,20. Methanolic leaf extract has reduced the increased creatinine levels when compared to the control group. Widely used in ivory coast and subsaharan africa in traditional medicine as antiinflammatory, antioxidant, laxative and purgative, erythrococca anomala euphorbiaceae, is an annual plant. The methanol extract of the fruit pulp of adansonia digitata l. Cinnamomum verum is an evergreen tree that is widely used as cinnamon spice. The results showed antioxidant activity using dpph were found to be increased in a concentration dependent.
The results showed that root extract exhibited the greatest free radical scavenging activity among the plant extracts with a mean percentage of 32. Free radical scavenging activity was determined by using a stable free. Evaluation of hepatoprotective activity of adansonia digitata. Edible coatings have encountered considerable attention in recent. Hepatoprotective activity of alcoholic and aqueous. Indeed, plant extracts usually possess variable amounts of phenolic and polyphenolic compounds, which are responsible for the. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. Quantification of the antioxidant activity of plant extracts mdpi. In postharvest technology, biopreservation aims at extending storageshelf life of fruits and vegetables by utilizing natural plant based products. Ovicidal, larvicidal and antiovipositional activities of bifora radians and other plant extracts on the grape berry moth paralobesia viteana clemens ayhan go.
Consequently, the search and study of plant extracts that have the highest antiradical and antioxidant activity aoa is a very urgent task. Evaluation of hepatoprotective activities aqueous and. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. In vitro antioxidant and in vivo hepatoprotective activity. Pdf nematicidal activity of plant extracts against the root.
The aqueous and methanolic extracts of dobera glabra leaves in two doses, did not affect either the elevated level of the hepatic enzymes induced by ccl4 or protectively from liver. Thus, the present study was conducted to evaluate the hepatoprotective activity of the pongamia pinnata bark. Hepatoprotective and antioxidant activity of bombax ceiba. The aim of this study was to investigate the hepatoprotective activity and antioxidant capacity of the water extract of e. Anticancer activity, antioxidant activity, and phenolic. Efficacy of plant extracts against the larvae of filariasis. Evaluation of hepatoprotective activity of eriocaulon.
Eml corresponds to methanol extract, ehl to to hexane extract, ecl to chloroform extract, eel to ethanol extract, and eal to aqueous extract. Antioxidant activity and cytotoxicity of the leaf and bark extracts of. Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by. Antiproliferative activity of plant extracts used against. In these works aoa are given in units % mg, mgml or mgg, that character. Such results were different from data reported in literature. The hepatoprotective effect of ethanolic bark extract of. Evaluation of some plant extracts for their nematicidal. Hepatoprotective activity of ethanolic extract of salix. The antimicrobial effects of the plant extracts are sufficient in a way to cater the healing effect. Leaf extracts were given in the dose of 200 mgkg body weight for 7 days and toxicity was induced by paracetamol 2 gkg on day 5. Antioxidant and hepatoprotective activities of ethanolic. In recent years, interest in the hepatoprotective plants and plant based chemicals is increasing. Antimicrobial activity of crude extracts of three medicinal.
The alcoholic extract was found to exhibit greater hepatoprotective activity than the aqueous extract. The extracts were analyzed for their total phenolic content tpc, total flavonoid content tfc, and antioxidant activity. In addition, hepatospecific serum markers will be disturbed. Thus, the present study was carried out to identify the hepatoprotective activity of plant parts leaf, bark, collar, flower and hypocotyls of c. The plant is medicinally used against gastrointestinal conditions and has antiinflammation pharmacological activity. Antioxidant and antibacterial activity of different parts of leucas aspera. Hepatoprotective effect of three herbal extracts on aflatoxin. Evaluation of hepatoprotective activity of adansonia.
The hepatoprotective activity of lle may be due to its free radicalscavenging and antioxidant activity, resulting from the presence of some flavonoids and phenolic compounds in the extracts. This present investigation was aimed to assess the hepatoprotective activity of aqueous and ethanol extract of pongamia pinnata leaves against acetaminopheninduced liver damage in albino rats. Evaluation of some plant extracts for their nematicidal properties against rootknot nematode, meloidogyne incognita m. The present study is used to investigate the hepatoprotective activity of ethanolic bark extract of terminalia arjuna on paracetamol induced liver damage. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities like sgpt, sgot, alp, and tb, which was supported by histopathological studies of liver. Methods for preparation of plant extracts, whole plants of s. A lot of herbal plants and polyherbal formulations are used for the treatment of liver diseases. Hepatoprotective activity of white horehound marrubium vulgare extract against cyclophosphamide toxicity in male rats.
Exhaustive literature survey shows that very few research work has been carry out in the plant croton sparciflorus. In folklore medicine, ceriops decandra is used to treat hepatitis. New drugs from plant secondary metabolites are being developed and studied for their antibacterial and anticancer activities 5. It is concluded that the aqueous extract of leaves of guava plant possesses good hepatoprotective activity. Hepatoprotective activity of ceriops decandra griff. Phytochemistry and hepatoprotective activity of aqueous. The aqueous extract showed significant hepatoprotective activity comparable with standard drug silymarin as well as hepatotoxin drug pcm. All of these plants have been scientifically investigated through experimental animal models which confirmed their hepatoprotective activities. Activity of plant extracts for preserving functional food. In vivo hepatoprotective potential of extracts obtained. Antibacterial activity of hot aqueous and methanolic extracts prepared from six plants terminallia chebula, terminallia bellerica, phyllanthus emblica, punica granatum, lawsonia alba and mikania micrantha used in traditional folk medicines of india were screened against five pathogenic bacteria staphylococcus aureus mtcc 2940, bacillus subtilis mtcc 441, escherichia coli mtcc 739, proteus. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Hepatoprotective activity of methanol extract of some.
Comparative hepatoprotective activity of ethanolic. Roja ramani3, prasanta kumar choudhury1 1,1department of pharmacology, royal college of pharmacy and health sciences, berhampur, odisha 760002. In the present report all the plant samples showed the presence of alkaloids, flavonoids, tannins and saponins. Medicinal plants possessed hepatoprotective activity. These findings revealed that feijoa sellowiana is an effective hepatoprotective plant.
Bioactive aqueous extracts of twelve yucatecan plants. Total capacity antioxidant activity from plant extracts. Plant extracts were dissolved in 20% dmso treated water. In the present study, lle possessed strong hepatoprotective and antioxidant activity in a rat model of ccl 4induced. Therefore, the hepatoprotection of the leaf extracts of p. Research article anticancer activity, antioxidant activity. In vitro antioxidant and in vivo hepatoprotective activity of leave extract of raphanus sativus in rats using ccl4 model. The observed hepatoprotective activity of the leaf.
Antioxidant activity of some algerian medicinal plants. Efficacy of plant extracts against the larvae of filariasis vector, culex quinquefasciatus say and the dengue vector aedes aegypti linn at mysore s. Decoction prepared from the whole plant of eriocaulon quinquingulare is prescribed to treat liver disorders. Gunturu abhilash 1, y uma maheswari 2, j avinash gopal 3, and dilip chanda 4. Overall, necrosis in the liver parenchyma was decreased. Antiinflammatory activity of leaf extracts of kalanchoe. These results suggest that all plant extracts are good inhibitors at low concentrations. Insecticidal activity of three plants extracts against myzus. The aim of the studywas to evaluate the antifungal activity of extracts of 10 plant species used in traditional. Antioxidant and antiproliferative activities of leaf extracts. The number of eggs hatched in control and treated were recorded and percentage of ovicidal activity calculated. The alcoholic extracts of aerial parts of vernonia cinerea has been examined for the effect of petroleum ether, ethyl acetate on cisplatininduced nephrotoxicity at a dose of 6mgkg, i. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. In hepatotoxic rats, liver damage was studied by assessing the levels of the enzymes alanine transaminase alt, aspartate transaminase ast, alkaline phosphatase acp and total.
There are many plants and traditional formulations available to treat the liver diseases 5, 6. Nematicidal activity of plant extracts against the rootknot nematode, meloidogyne incognita article pdf available in the open natural products journal 21 october 2009 with 2,550 reads. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models. Notably, it is a referred, highly indexed, online international journal with high impact factor. To assess the in vivo antioxidfant and hepatoprotective activity of methanolic extract of daucus carota d. The methanol extracts of plant materials of some plants like casuarina equisetifolia, cajanus cajan, glycosmis pentaphylla, bixa orellana, argemone mexicana, physalis minima, caesalpinia bonduc, belonging to the different family were studied for hepatoprotective activity against swiss albino rats with liver damage induced by carbon tetrachlorideccl. Hepatoprotective and antioxidant activity of ethanolic. The hepatoprotective activity of eeih might be attributed to the flavonoid compounds such as catechin 1, 3. Antimicrobial activity was tested using a modified disc diffusion assay dda method originally described by bauer 1966 and ncube et al 2008. Ethanol, hepatoprotective activity, leaf extracts, tylophora indica. Study of the hepatoprotective activity of methanolic. This study investigates the comparative hepatoprotective activity of crude ethanol extracts of cuscuta australis against acetaminophen apap intoxication.
Extracts from a broad spectrum of plant species contain substances that possess antitumor activity 1. Jun 18, 2003 the ability of antioxidants obtained from natural sources to stabilise foodstuffs containing long n3 fatty acids of marine origin has been determined. Preliminary phytochemical analysis of the extracts of psidium. Numerous works devoted to antioxidant activity of plant extracts are published. Hepatoprotective activity of white horehound marrubium. Vijayan department of studies in zoology, university of mysore, mansagangothri, mysuru570006, india corresponding author abstract. Production of reactive oxygen species is a common cause in alcohol induced liver diseases. A large number of plants and formulations have been claimed to show hepatoprotective activities. Hepatoprotective activity of ethanolic extract of salix subserrata against ccl 4induced chronic hepatotoxicity in rats. Antimicrobial activity of some plant extracts against. Identification and characterization of plant extracts as a potential indian j. Baskaran abstract nematicidal activities of extracts from plants were assayed against meloidogyne incognita.
International journal of science and research ijsr is published as a monthly journal with 12 issues per year. Antibacterial activity of plant extracts 247 brazilian journal of microbiology 2000 31. Research article anticancer activity, antioxidant activity, and phenolic and flavonoids content of wild tragopogon porrifolius plant extracts fuadalrimawi, 1 suzirishmawi, 2 sharehanh. Plant extracts showed no cytotoxicity against normal. The inoculums for each microorganism were prepared from broth cultures 105 cfuml. The ld50 and in vivo hepatoprotective activity carried out with the leaf extract the most potent. Evaluation of nephroprotective activity of the methanolic. Comparative hepatoprotective activity of ethanolic extracts of cuscuta australis against acetaminophen intoxication in wistar rats rachaelo. The axis corresponds to mg of ascorbate acid equivalents eeag and the axis, the plant extract. Antioxidant activity of the plant extracts were characterized by using dpph free radical scavenging method. Ovicidal, larvicidal and antiovipositional activities of. Hepatoprotective activity of methanol extract of melastoma. Hepatoprotective effect of poly herbal formulation against.
Antioxidant, plant extracts, ethyl acetate fraction, oxidative. Methanolic leaf extract of the plant has significant nephroprotective activity. Pdf hepatoprotective activity of some plants extract. The results revealed that the activities of sgot and sgpt were seriously decreased and gsh level was significantly increased by the feijoa extract. Hepatoprotective activity of methanolic extract of. Khalid, 2 ismailwarad, 3 andzaidounsalah 2 chemistry department,facultyof science and technology,alqudsuniversity, p. Around 160 active constituents from 101 plants are claimed to have post liver protecting activity. Ten dif ferent plants were collected from in and around sivakasi area.
Evaluation of antioxidant, antihemolytic and anticancer activity of. Materials and methods the preliminar y investigations for the antiinflammator y activity plant material of the various fractions on paw edema induced by carrageenan. Plants were fractionated using ethanol, methanol, chloroform, nhexane, distilled water, and butanol. These results show that the aqueous extracts of five native plants of the. Research article phytochemical analysis of some traditional. Keeping this view in the mind, bark extracts of terminalia catappa was selected for to evaluate the hepatoprotective activity. Hepatoprotective activity of the methanolic extract of the. The current research aimed to investigate the antibacterial activity shown by the extracts prepared from different parts of olea europea, myrtus communis, thymus vulgaris, rosmarinuis officinalis, and achillea falcata that grow in syria against a. Bello abstract phytochemicalsare active secondary plant metabolites responsible for most of the claimed medicinal activities of plants. Increasingly, natural products have potential for the treatment of cancer. Administration of plant extract at a dose of 300 mgkg. In this work, the aim was to evaluate the hepatoprotective activity of the aqueous and hydroethanolic extracts of the leaves.
Rajendaran1, durga jaiswal2, hari pratap singh3, ashutosh mishra3, dinesh chandra4, indranil kumar yadav5and d. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. It showed that gpx, gst, sod and catalase activity were significantly decrease in simvastatin intoxicated rats when compared with those animals in normal control group on the other hand the groups with received both leaf extracts 300mgkg, and 500mgkg, and. B 250 mgkg and 500 mgkg produced p download fulltext pdf. Evaluation on antioxidant properties of sixteen plant species from. Airdried seeds 2 kg were finely ground and soaked in petroleum ether 60 80 1. Conclusion the present study leads to the further research in the way of isolation and identification of the activity compound from the selected plants using chromatographic and spectroscopic techniques. Antioxidant and in vitro cytotoxic activity of extracts of. It was stored in a well closed container free from environmental climatic changes till usage. Antioxidant activity of spilanthes acmella extracts.
Antioxidant, antihypertensive, antihyperglycemic, and. Aqueous and alcoholic extracts of terminalia catappa were taken. The first step to quantify the antioxidant activity of a plant extract is to select the right method 9. So an attempt has been made for the first time to investigate the cardioprotective activity of the plant through curative mode of treatment. Ovicidal activity of plant extracts against litura. Pdf medicinal plants possessed hepatoprotective activity. In vitro antioxidant study carried out with dpph, hrsa, no, frap and lpo assays. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim abstract the aim of the study is to investigate the hepatoprotective activity of melia azedarach leaves extracts against simvastatin induced hepatotoxicity.
Review on some medicinal plants with hepatoprotective. The cytotoxic activity of the extracts of cocculus hirsutus on mcf7 cells was investigated in vitro through mtt assay. The objective of this study was to investigate the hepatoprotective activity of methanol extract of. In vivo antioxidant and hepatoprotective activity of. Hepatoprotective activity of ethanol extract of conyza b. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. Insecticidal activity of three plants extracts against myzus persicae sulzer, 1776 and their phytochemical screening acta agriculturae slovenica, 105 2, september 2015 265 table 2. Food systems enriched in polyunsaturated fatty acids pufa were. The results of antimicrobial activity showed that water and ethanol crude extracts were active on all the strains of pathogens tested at different concentrations, with ethanol extracts exerting more activity. Antioxidants free fulltext hepatoprotective effect of.
Hepatoprotective effect of leaf extracts from citrus. Pcmintoxication model is a universally established model to study the potential hepatoprotective activity of extracts. Based on the preliminary screening, the effective plant extracts were further tested at a concentration of 0. Antisnake venom activity of different extracts of pouzolzia indica against russel viper venom anas ahmed1, k. The antioxidant activity measurements of ethanolic extracts, expressed as trolox equivalent antioxidant capacity teac are presented in table 3. Hepatoprotective activity of some medicinal plants in sudan. In india, numerous medicinal plants are used for the treatment of liver disorders. Results of antimicrobial activity of the five plant extracts can suggested that s. The root bark of illicium henryi has been used in traditional chinese medicine to treat lumbar muscle strain and rheumatic pain.
Hepatoprotective activity of cinnamon ethanolic extract. Antibacterial activity of various plants extracts against. Association of antibiotics and plant extracts showed synergistic antibacterial activity against antibioticresistant bacteria. Hepatoprotective and antioxidant activity of bombax ceiba flowers against carbon tetrachlorideinduced hepatotoxicity in rats hepatoma research is an open access journal and focuses on all topics related to hepatoma. Cardioprotective activity of methanolic extract of roton. The antioxidant activity of the aqueous leaf extract aq lf. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim.
The present investigation is aimed to evaluate the hepatoprotective effects of citrus hystrix and citrus maxima red and white variety methanolic leaf extracts on paracetamol induced toxicity. This has been observed by estimating the bio markers and listed in the above table. The antioxidant activities of the leaves and stem bark methanol and ethyl acetate extracts of plant material. The objective of this study was to investigate the hepatoprotective activity of methanol extract of leaves of orthosiphon stamineus. Studies on hepatoprotective activity of hydroalcoholic leaf extract of pongamia pinnata against ir induced hepatic reperfusion injury saiprasanna behera1, s. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4. Antioxidant and hepatoprotective effects of solanum xanthocarpum leaf extracts against ccl4induced liver injury in rats. Furthermore, the subchronic toxicological investigations were done to evaluate the adverse toxic signs and effects of the plant that possess hepatoprotective activity.
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